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Dorene Kastelman, talks PARP inhibitors, BRCA, and living with stage 4 ovarian cancer.
  • 21/07/2017
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Dorene Kastelman, talks PARP inhibitors, BRCA, and living with stage 4 ovarian cancer.

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Descripción de Dorene Kastelman, talks PARP inhibitors, BRCA, and living with stage 4 ovarian cancer.

Our third guest this week is Dorene Kastelman, a BRCA mutation carrier and a stage 4 ovarian cancer survivor. Shortly after testing positive for a BRCA mutation, Dorene entered a clinical trial that was testing the efficacy of a specific PARP inhibitor for late-stage ovarian cancers thought to be associated with BRCA mutations. When the clinical trial ended, Dorene discovered she had been in the placebo or control group the whole time, and her cancer was returning. Luckily, after a few months of searching for another clinical trial, Dorene learned that the FDA approved the PARP inhibitor Olaparib (Lynparza), and she has been taking it twice a day ever since. Dorene’s story is a wonderful example of the importance of approaching cancer research and treatment in unique ways.

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